Anatomical Pathology
COMPREHENSIVE HISTOpathology SERVICES
Delivering precise histological and immunohistochemical insights tailored for cancer.
At nexomics we deliver accredited, clinical-grade diagnostic services including comprehensive histology, a full suite of key cancer biomarker assays and advanced whole-slide-imaging (WSI) services backed by pathology experts.
Our services Includes:
- Tissue Processing, embedding, and sectioning for downstream biomarker analysis.
- Histopathology Services including special stains and a full suite of IHC/CISH biomarker assays (both routine diagnostic and bespoke assays).
- A range of Immunohistochemistry (IHC) and In-Situ Hybridization (ISH) stains.
- Digital Pathology Services including whole slide imaging and second opinion reporting.
- Expert Opinion and Consultation including pathologist biomarker advice and bespoke scoring algorithms.
Foundation for Advanced cancer Biomarker Analysis
Tissue Processing and Sectioning
Nexomics provides comprehensive tissue processing (paraffin embedding and sectioning) and the application of both downstream Immunohistochemistry (IHC) and In Situ Hybridization (ISH) staining for deeper biological insights.
Histopathology Services
Consistent Stains. Reliable Results.
- Our pathologists commonly use a range of special stains to selectively stain against specific structures or cellular components and tissues which aid in investigating the presence of tumour-infiltrating lymphocytes (TILs) and stromal TILs in clinical samples, while also identifying any pathological changes.
- Our Haematoxylin and Eosin (H&E) staining services provide a reliable view of cellular and tissue structures in formalin-fixed paraffin-embedded, fresh frozen tissue, or cytology specimens.
supporting exploratory research and advancing clinical trials through reliable biomarker stains
Immunohistochemistry (IHC) and In Situ Hybridization (ISH)
Immunohistochemistry (IHC) and In Situ Hybridization (ISH) biomarkers play a crucial role in modern drug development by providing insights into gene and protein expression.
At nexomics, our expert team leverages a comprehensive genomically annotated tissue, controls and cell line repository to meticulously develop, validate and implement (ISO 17025 and 15189) such assays. These assays are integral to supporting exploratory research and advancing clinical trials.
Our integrated routine and clinical trial service:
- Offers more than 235 novel and routine IHC / ISH assays performing more than 60,000 IHC stains annually.
- Supports in-house IVD and FDA-approved companion diagnostic IHC stains for retrospective or prospective clinical trial samples.
- Our services are platform agnostic and backed by well-established sample processing protocols to support small to large-scale clinical trials.
COMPREHENSIVE ANATOMICAL PATHOLOGY SERVICES.
Comprehensive Histopathology Services.
235+
Unique IHC / ISH validated assays
60,000+
IHC stains performed annually
Featured IHC Biomarkers
We offer specialised immunohistochemistry (IHC) testing, which complement our portfolio of comprehensive genomic profiling (CGP) tests for clinical trial clients.
- ALK (Clone D5F3)
- EGFR (Clone 3C6)
- HER2 (Clone 4B5)
- MMR: MLH1 (Clone ES05), PMS2 (Clone G219-1129), MSH2 (Clone SP93), MSH6 (Clone A16-4)
- PD-L1 (Clones: SP263, 22C3, SP142)
- ROS1 (Clone SP384)
digital PATHOLOGY imaging services
Digital Slide Records. Translational Pathology.
We offer whole slide digital imaging (WSI) as a service where clinically tested and reported cases with H&E, ISH and IHC reported slides, are digitally scanned and readily available for transfer to clinical trial data teams, global pathology networks for second opinion reviews and digital pathology collaborators.
board-certified pathologists
Internationally recognised. Specialised Advice.
At nexomics our access to on-site pathologists committed to advancing clinical research, ensures meticulous quality control and comprehensive analysis of your samples.
Through this integrated service offering we support every aspect of clinical research, from biomarker discovery and evaluation to the development of in-house IVDs or laboratory developed tests (LDTs), companion diagnostics (CDx) and in vitro diagnostics (IVD).
COMPREHENSIVE ANATOMICAL PATHOLOGY SERVICES.
Comprehensive Histopathology Services.
Range of Histology Services
- Supporting sample characterisation and assay validation.
- Tissue processing, paraffin embedding, sectioning and staining.
- Use of in-house IVDs , laboratory-developed tests (LDT) and FDA-approved companion diagnostic (CDx) IHC stains on archived or client-provided tissue specimens.
- Whole slide digital imaging and data transfer support services.
Bespoke Service Offering
- Customised pathology services to get the most out of your tissue samples.
- Board-certified pathologist scoring, and experience in patient enrolment.
- Scientifically driven expertise in study design, assay transfers, and validations.
- Study consultation and bespoke scoring algorithm development.
Precision Analysis and Reporting
- Oncology specialty lab delivering deeper characterisation and analysis of your clinical samples.
- Ability to transfer, optimise, & validate client proprietary or commercially available IHC stains.
- Tumour and tissue assessment and microdissection of samples for RNAseq or NanoString analysis.
- Analysis of samples in support of companion diagnostic development (CDx).
Sub-Specialty Pathology Expertise
- Integrated on-site pathologists offer their specialised knowledge and valuable time to partners interested in exploring assay development.
- Supported by our team of scientists, our pathologists can provide valuable insights into the clinical relevance of exploratory biomarker analysis.
